methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate

Base Information

• Chemical Name: methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate
• CAS No.: 1202778-98-0
• Molecular Formula: C₂₀H₁₅F₆NO₂
• Molecular Weight: 415.335
• Mol file: 1202778-98-0.mol

Synonyms:methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate

Chemical Property of methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate

There total 4 articles about methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromomethyltrifluoromethylbenzene (402-49-3) + methyl 2-cyanoacetate (105-34-0) → methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate (1202778-98-0)

Guidance literature:

methyl 2-cyanoacetate; With sodium methylate; In methanol; at 20 ℃;

4-bromomethyltrifluoromethylbenzene; In methanol; Reflux;

DOI:10.1021/jm901052r

Reference yield:

methyl 2-cyano-3-(4-(trifluoromethyl)phenyl)propanoate (676272-24-5) + 4-bromomethyltrifluoromethylbenzene (402-49-3) → methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate (1202778-98-0)

Guidance literature:

methyl 2-cyano-3-(4-(trifluoromethyl)phenyl)propanoate; With sodium methylate; In methanol; at 20 ℃; for 0.0833333h;

4-bromomethyltrifluoromethylbenzene; In methanol; at 78 ℃; for 0.25h; Reflux;

DOI:10.1021/jm101327d

Reference yield:

4-bromomethyltrifluoromethylbenzene (402-49-3) → methyl 2-cyano-3-[4-(trifluoromethyl)phenyl]-2-{[4-(trifluoromethyl)phenyl]methyl}propionate (1202778-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 0.08 h / 20 °C

1.2: 0.25 h / 78 °C / Reflux

2.1: sodium methylate / methanol / 0.08 h / 20 °C

2.2: 0.25 h / 78 °C / Reflux

With sodium methylate; In methanol;

DOI:10.1021/jm101327d

upstream raw materials:

4-bromomethyltrifluoromethylbenzene

methyl 2-cyanoacetate

methyl 2-cyano-3-(4-(trifluoromethyl)phenyl)propanoate

Downstream raw materials:

methyl 3-amino-2,2-bis{[p-(trifluoromethyl)phenyl]methyl}propionate

C₂₅H₂₇F₆NO₄

C₂₄H₂₅F₆NO₄

C₇H₈O₃S*C₂₀H₁₉F₆NO₂