methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside

Base Information

Chemical Name:methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside
CAS No.:108399-88-8
Molecular Formula:C₅₃H₆₄O₁₁Si
Molecular Weight:905.17
Hs Code.:

Synonyms:methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside

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Chemical Property of methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside

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Technology Process of methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside

There total 5 articles about methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.2%

: 108399-87-7
(3aS,4S,6R,7aR)-4-((2S,3S,4S,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-methoxy-tetrahydro-pyran-3-yloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-one

: 108399-88-8
methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h;
DOI:10.1016/S0008-6215(00)90299-4

Reference yield:

: 107937-20-2
methyl 3,4,6-tri-O-benzyl-2-O-α-D-mannopyranosyl-α-D-mannopyranoside

: 108399-88-8
methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: 79.7 percent / p-toluenesulfonic acid monohydrate / various solvent(s) / 0.5 h / Ambient temperature

3: 65.4 percent / pyridinium chlorochromate, 3A molecular sieves / CH₂Cl₂ / Ambient temperature

4: 88.2 percent / sodium borohydride / aq. ethanol / 1 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; 3 A molecular sieve; toluene-4-sulfonic acid; pyridinium chlorochromate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)90299-4

Reference yield:

: 108399-86-6
methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-α-D-mannopyranosyl>-α-D-mannopyranoside

: 108399-88-8
methyl 3,4,6-tri-O-benzyl-2-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1: 79.7 percent / p-toluenesulfonic acid monohydrate / various solvent(s) / 0.5 h / Ambient temperature

2: 65.4 percent / pyridinium chlorochromate, 3A molecular sieves / CH₂Cl₂ / Ambient temperature

3: 88.2 percent / sodium borohydride / aq. ethanol / 1 h / 0 °C

With sodium tetrahydroborate; 3 A molecular sieve; toluene-4-sulfonic acid; pyridinium chlorochromate; In ethanol; dichloromethane;
DOI:10.1016/S0008-6215(00)90299-4