5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester

Base Information

Chemical Name:5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester
CAS No.:1026840-83-4
Molecular Formula:C₁₅H₁₆N₂O₄S
Molecular Weight:320.369
Hs Code.:

Synonyms:5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester

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Chemical Property of 5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester

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Technology Process of 5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester

There total 8 articles about 5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7499-07-2
4-chloro-2-methylbenzoic acid

: 1026840-83-4
5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: ClSO₃H / 6 h / 135 - 140 °C

2: aq. Na₂SO₃, aq. NaOH / 15 - 20 °C

3: aq. NaOH / methanol / 30 h / Heating

4: 88 percent / 4 h / 160 °C

5: 92 percent / H₂ / 10percent Pd/C / methanol / 3 h / 45 °C / 760 Torr

6: 1.) NaH / 1.) N-methylpyrrolidin-2-one, RT, 2 h, 2.) N-methylpyrrolidin-2-one, 100 deg C, 48 h

7: HCl / 6 h / Heating

With hydrogenchloride; chlorosulfonic acid; sodium hydroxide; hydrogen; sodium hydride; sodium sulfite; palladium on activated charcoal; In methanol;
DOI:10.1021/jm960768n

Reference yield:

: 213121-77-8
2-chloro-4-methyl-5-carboxybenzenesulfinic acid

: 1026840-83-4
5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH / methanol / 30 h / Heating

2: 88 percent / 4 h / 160 °C

3: 92 percent / H₂ / 10percent Pd/C / methanol / 3 h / 45 °C / 760 Torr

4: 1.) NaH / 1.) N-methylpyrrolidin-2-one, RT, 2 h, 2.) N-methylpyrrolidin-2-one, 100 deg C, 48 h

5: HCl / 6 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In methanol;
DOI:10.1021/jm960768n

Reference yield:

: 176309-00-5
2-methyl-4-chloro-5-methyl-sulfonylbenzoic acid

: 1026840-83-4
5-Methanesulfonyl-2-methyl-4-(pyridin-2-ylamino)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / 4 h / 160 °C

2: 92 percent / H₂ / 10percent Pd/C / methanol / 3 h / 45 °C / 760 Torr

3: 1.) NaH / 1.) N-methylpyrrolidin-2-one, RT, 2 h, 2.) N-methylpyrrolidin-2-one, 100 deg C, 48 h

4: HCl / 6 h / Heating

With hydrogenchloride; hydrogen; sodium hydride; palladium on activated charcoal; In methanol;
DOI:10.1021/jm960768n