methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate

Base Information

• Chemical Name: methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate
• CAS No.: 1123216-99-8
• Molecular Formula: C₂₅H₂₇BrN₂O₃
• Molecular Weight: 483.405
• Mol file: 1123216-99-8.mol

Synonyms:methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate

Chemical Property of methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate

There total 4 articles about methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

salicylaldehyde (90-02-8) + methyl 12-bromo-13,14-diaminodeisopropyldehydroabietate (671820-50-1) → methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate (1123216-99-8)

Guidance literature:

With air; In 1,4-dioxane; for 5h; Reflux;

DOI:10.3390/molecules16010100

Reference yield:

dehydroabietic acid (1740-19-8) → methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate (1123216-99-8)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate; p-toluenesulfonyl chloride

2: N-Bromosuccinimide

3: sulfuric acid; nitric acid

4: 10% palladium on activated charcoal; hydrogen / ethanol

5: air / 1,4-dioxane / 5 h / Reflux

With N-Bromosuccinimide; sulfuric acid; 10% palladium on activated charcoal; hydrogen; nitric acid; potassium carbonate; p-toluenesulfonyl chloride; In 1,4-dioxane; ethanol;

DOI:10.3390/molecules16010100

Reference yield:

Methyl dehydroabietate (1235-74-1,1757-97-7,2756-34-5,7151-00-0,10178-27-5,10178-29-7,21699-55-8,24035-60-7) → methyl 2'-hydroxyphenyl-12-bromo-13,14-imidazolyl-deisopropyldehydroabietate (1123216-99-8)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide

2: sulfuric acid; nitric acid

3: 10% palladium on activated charcoal; hydrogen / ethanol

4: air / 1,4-dioxane / 5 h / Reflux

With N-Bromosuccinimide; sulfuric acid; 10% palladium on activated charcoal; hydrogen; nitric acid; In 1,4-dioxane; ethanol;

DOI:10.3390/molecules16010100

upstream raw materials:

(1R,4aS,10aR)-methyl 6-bromo-1,2,3,4,4a,9,10,10aoctahydro-7-isopropyl-1,4a-dimethylphenanthrene-1-carboxylate

dehydroabietic acid

Methyl dehydroabietate

salicylaldehyde