1-amino-4-(tris(pyrazol-1-yl)methyl)benzene

Base Information

• Chemical Name: 1-amino-4-(tris(pyrazol-1-yl)methyl)benzene
• CAS No.: 1000389-71-8
• Molecular Formula: C₁₆H₁₅N₇
• Molecular Weight: 305.342
• Mol file: 1000389-71-8.mol

Synonyms:1-amino-4-(tris(pyrazol-1-yl)methyl)benzene

Chemical Property of 1-amino-4-(tris(pyrazol-1-yl)methyl)benzene

Chemical Property:

Purity/Quality:

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Technology Process of 1-amino-4-(tris(pyrazol-1-yl)methyl)benzene

There total 1 articles about 1-amino-4-(tris(pyrazol-1-yl)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

NH-pyrazole (288-13-1) + 4-trifluoromethylphenylamine (455-14-1) → 1-amino-4-(tris(pyrazol-1-yl)methyl)benzene (1000389-71-8)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; for 1h; Heating;

DOI:10.1021/jo701924w

Reference yield: 99.3%

1-amino-4-(tris(pyrazol-1-yl)methyl)benzene (1000389-71-8) → 4-hydroxy-benzoic acid (99-96-7)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 100 ℃; for 0.75h; Concentration; Cooling with ice;

Reference yield: 98.0%

1-amino-4-(tris(pyrazol-1-yl)methyl)benzene (1000389-71-8) + [Rh(norbornadiene)2][B(3,5-(CF3)2C6H3)4] (666826-18-2) → [(p-tris(pyrazol-1-yl)toluidine)Rh(norbornadiene)][B(C6H3-3,5-(CF3)2)4] (1319719-41-9)

Guidance literature:

In tetrahydrofuran; under N2, Schlenk technique; soln. of tris(pyrazol-1-yl)toluidine and Rhcomplex in THF stirred at room temp. for 20 to 30 min; concn. under vac., recrystn. from CH2Cl2/n-pentane; elem. anal.;

DOI:10.1039/c1nj20094a

upstream raw materials:

NH-pyrazole

4-trifluoromethylphenylamine

Downstream raw materials:

[(p-tris(pyrazol-1-yl)toluidine)Rh(norbornadiene)][B(C₆H₃-3,5-(CF₃)2)4]

[(p-tris(pyrazol-1-yl)toluidine)Rh(1,5-cyclooctadiene)][B(C₆H₃-3,5-(CF₃)2)4]

4-hydroxy-benzoic acid