(1S,5R)-5-isopropyl-2-methylene cyclohexanol

Base Information

• Chemical Name: (1S,5R)-5-isopropyl-2-methylene cyclohexanol
• CAS No.: 7070-05-5
• Molecular Formula: C₁₀H₁₈O
• Molecular Weight: 154.252
• Mol file: 7070-05-5.mol

Synonyms:(1S,5R)-5-isopropyl-2-methylene cyclohexanol

Chemical Property of (1S,5R)-5-isopropyl-2-methylene cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (1S,5R)-5-isopropyl-2-methylene cyclohexanol

There total 8 articles about (1S,5R)-5-isopropyl-2-methylene cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-3-isopropyl-6-methyl-7-oxabicyclo[4.1.0]heptane (851520-66-6) → (1S,5R)-5-isopropyl-2-methylene cyclohexanol (7070-05-5) + (1R,5R)-5-isopropyl-2-methylene cyclohexanol (93302-57-9)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; for 2h; Yields of byproduct given; Heating;

DOI:10.1002/hlca.19840670511

Reference yield:

cis-(R)-limonene oxide (4680-24-4) → (1S,5R)-5-isopropyl-2-methylene cyclohexanol (7070-05-5)

Guidance literature:

Multistep reaction; (i) H₂, PtO₂, AcOEt, (ii) NaOAc, AcOH, (iii) (pyrolysis);

DOI:10.1021/jo01344a062

Reference yield:

(+)-N,N-1-dimethylaminoneodihydrocarveol (111613-36-6) → (1S,5R)-5-isopropyl-2-methylene cyclohexanol (7070-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney-Ni / methanol

2: (i) aq. H₂O₂, MeOH, (ii) (pyrolysis)

With hydrogen; nickel; In methanol;

upstream raw materials:

(3R)-3-isopropyl-6-methyl-7-oxabicyclo[4.1.0]heptane

trans N,N-dimethylamino-1 neocarvomenthol

cis-(R)-limonene oxide

(+)-p-menth-1-ene

Downstream raw materials:

p-Menth-1⁽⁷⁾-ene-2-ol-nitrat

trans-(1S,5R)-5-isopropyl-2-methyl-2-cyclohexen-1-ol