6-chloro-1H-Indole-5-carboxylic acid

Base Information

• Chemical Name: 6-chloro-1H-Indole-5-carboxylic acid
• CAS No.: 256935-86-1
• Molecular Formula: C9H6 Cl N O2
• Molecular Weight: 195.605
• Hs Code.: 2933990090
• Mol file: 256935-86-1.mol

Synonyms:5-carboxylic-6-chloro indole acid;6-chloro-5-indole carboxylic acid;6-chloroindole-5-carboxylic acid;1H-Indole-5-carboxylicacid,6-chloro;QC-9758;

Chemical Property of 6-chloro-1H-Indole-5-carboxylic acid

Chemical Property:

• Boiling Point: 434.4±25.0 °C(Predicted)
• PKA: 3.24±0.30(Predicted)
• PSA: 53.09000
• Density: 1.548
• LogP: 2.51950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-chloro-1H-indole-5-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-1H-Indole-5-carboxylic acid

There total 3 articles about 6-chloro-1H-Indole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

6-chloro-2-ethoxycarbonyl-5-methoxycarbonyl-indole → 6-chloro-indole-5-carboxylic acid (256935-86-1)

Guidance literature:

6-chloro-2-ethoxycarbonyl-5-methoxycarbonyl-indole; With sodium hydroxide; water; for 1h; Heating;

With hydrogenchloride; for 2h; Heating;

DOI:10.1016/j.tetlet.2007.01.148

Reference yield:

6-chloro-1H-indole-5-carboxylic acid methyl ester (162100-83-6) → 6-chloro-indole-5-carboxylic acid (256935-86-1)

Guidance literature:

With sodium hydroxide; water; In methanol; at 50 ℃; for 4h;

Reference yield:

6-chloro-2-ethoxycarbonyl-7-iodo-5-methoxycarbonyl-indole (935676-17-8) → 6-chloro-indole-5-carboxylic acid (256935-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 100 percent / H₂ / Raney Ni / ethanol / 1 h

2.1: NaOH; water / 1 h / Heating

2.2: 60 percent / HCl / 2 h / Heating

With sodium hydroxide; water; hydrogen; nickel; In ethanol;

DOI:10.1016/j.tetlet.2007.01.148

upstream raw materials:

6-chloro-2-ethoxycarbonyl-7-iodo-5-methoxycarbonyl-indole

6-chloro-1H-indole-5-carboxylic acid methyl ester

Downstream raw materials:

6-chloro-(4-(4-fluorobenzyl) piperidinyl)indole-5-carboxamide