[2-(tert-butyldimethylsilanyloxy)ethyl]-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-yl)amine

Base Information

• Chemical Name: [2-(tert-butyldimethylsilanyloxy)ethyl]-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-yl)amine
• CAS No.: 1208346-67-1
• Molecular Formula: C₂₁H₂₉N₃O₂Si
• Molecular Weight: 383.566

Synonyms:[2-(tert-butyldimethylsilanyloxy)ethyl]-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-yl)amine

Chemical Property of [2-(tert-butyldimethylsilanyloxy)ethyl]-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-yl)amine

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Technology Process of [2-(tert-butyldimethylsilanyloxy)ethyl]-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-yl)amine

There total 1 articles about [2-(tert-butyldimethylsilanyloxy)ethyl]-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)-[2-(tert-butyldimethylsilanyloxy)ethyl]amine (1208346-66-0) + methylzinc chloride (5158-46-3) → [2-(tert-butyldimethylsilanyloxy)ethyl]-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-yl)amine (1208346-67-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 24h; Inert atmosphere; Reflux;

DOI:10.1002/cmdc.200900339

Reference yield: 95.0%

[2-(tert-butyldimethylsilanyloxy)ethyl]-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-yl)amine (1208346-67-1) → 2-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-ylamino)ethanol (1208346-54-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/cmdc.200900339

upstream raw materials:

(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)-[2-(tert-butyldimethylsilanyloxy)ethyl]amine

methylzinc chloride

Downstream raw materials:

2-(5-methyl-6-phenylfuro[2,3-d]pyrimidin-4-ylamino)ethanol

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