N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde

Base Information

Chemical Name:N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde
CAS No.:1337913-74-2
Molecular Formula:C₂₈H₂₉NO₄Si
Molecular Weight:471.628
Hs Code.:

Synonyms:N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde

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Chemical Property of N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde

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Technology Process of N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde

There total 2 articles about N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1337913-86-6
7-benzhydrylindole-3-carboxaldehyde

: 80149-80-0
2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate

: 1337913-74-2
N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde

Guidance literature:: 7-benzhydrylindole-3-carboxaldehyde; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Cooling with ice;

2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate; In tetrahydrofuran; mineral oil; at 20 ℃; for 12h;
DOI:10.1021/ol202535f

Reference yield:

: 135328-49-3
7-(diphenylmethoxy)indole

: 1337913-74-2
N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 20 h / 0 - 40 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Cooling with ice

2.2: 12 h / 20 °C

With sodium hydride; trichlorophosphate; In tetrahydrofuran; mineral oil;
DOI:10.1021/ol202535f

Reference yield: 84.0%

: 1337913-88-8
methyl (2,2-dichloropropionylamino)(dimethoxyphosphoryl)acetate

: 1337913-74-2
N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde

: methyl (Z)-2-(2,2-dichloropropionylamino)-3-(N-[(trimethylsilylethoxy)carbonyl]-7-benzhydryloxyindol-3-yl)acrylate

Guidance literature:: methyl (2,2-dichloropropionylamino)(dimethoxyphosphoryl)acetate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 0.333333h; Cooling with ice;

N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol202535f