135328-49-3

Basic information

• Product Name: 7-BENZHYDRYLOXYINDOLE
• Synonyms: 7-BENZHYDRYLOXYINDOLE;7-(Benzhydryloxy)-1H-indole;7-(benzhydryloxy)-indoline
• CAS NO: 135328-49-3
• Molecular Formula: C₂₁H₁₇NO
• Molecular Weight: 299.37
• Mol File: 135328-49-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 491.4°Cat760mmHg
• Flash Point: 174.8°C
• Appearance: /
• Density: 1.195g/cm³
• Vapor Pressure: 2.53E-09mmHg at 25°C
• Refractive Index: 1.675
• Storage Temp.: 2-8°C
• PKA: 16.15±0.30(Predicted)
• CAS DataBase Reference: 7-BENZHYDRYLOXYINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BENZHYDRYLOXYINDOLE(135328-49-3)
• EPA Substance Registry System: 7-BENZHYDRYLOXYINDOLE(135328-49-3)

Safety Data

• Hazardous Substances Data: 135328-49-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 21, p. 611, 1991 DOI: 10.1080/00397919108020827

InChI:InChI=1/C21H17NO/c1-3-8-17(9-4-1)21(18-10-5-2-6-11-18)23-19-13-7-12-16-14-15-22-20(16)19/h1-15,21-22H

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 776-74-9 Bromodiphenylmethane 
• 88-75-5 2-hydroxynitrobenzene 
• 67810-89-3 benzhydryl-(2-nitro-phenyl)-ether 

Downstream Products

• 1206199-54-3 1-(2-trimethylsilanylethoxymethyl)-7-diphenylmethoxyindole 
• 1206199-59-8 3-bromo-7-diphenylmethoxyindole 
• 897402-13-0 5-(3-bromophenyl)-5-(7-cyanomethoxy-1H-indole)pentanenitrile 
• 1337913-86-6 7-benzhydrylindole-3-carboxaldehyde 
• 1337913-74-2 N-[(trimethylsilylethoxy)carbonyl]-7-benzhydrylindole-3-carboxaldehyde 
• 1337913-78-6 C₃₁H₃₄N₂O₇ 
• 1337913-91-3 1,5-di-tert-butyl 4-methyl 10-benzyloxy-7-methylene-6-oxo-3,4,6,7-tetrahydroazocino[4,5,6-cd]indole-1,4,5-tricarboxylate 
• 1337913-90-2 methyl 10-benzyloxy-7-methylene-6-oxo-1,3,4,5,6,7-hexahydroazocino[4,5,6-cd]indole-4-carboxylate 
• 1315307-86-8 ethyl (7-benzhydryloxy-1H-indol-3-yl)glyoxylate 
• 1315307-77-7 6-hydroxy-2,5-dihydro-2-phenyl-4H-pyrazolo[3,4-c]quinolin-4-one 
• 1315307-75-5 6-benzhydryloxy-2,5-dihydro-2-phenyl-4H-pyrazolo[3,4-c]quinolin-4-one 
• 135328-50-6 7-(Cyanomethoxy)indole 
• 205877-09-4 (7-Benzhydryloxy-2,3-dihydro-1H-indol-2-yl)-acetic acid ethyl ester 

Relevant articles and documents

Synthetic approach to telomerase inhibitor dictyodendrin B: Synthesis of the pyrrolo[2,3-c]carbazole core

The core structure of the telomerase inhibitor, dictyodendrin B, was synthesized by using the palladium-catalyzed cross-coupling reaction of 3-aryl-1-(2-arylethyl)-4-hydroxy-2,5-bismethoxycarbonylpyrrole triflate with 7-alkoxyindole-3-boronate as the key step.

Therapeutic diphenyl ether ligands

This invention is directed to compounds of formula Ia, Ib or Ic and to pharmaceutical compositions thereof: or a prodrug thereof and a pharmaceutically acceptable carrier, wherein the R groups are defined in the specification; and, in which the dashed line represents an optional double bond. The invention is also directed to methods of treating, diagnosing, and preventing disorders of the central nervous system that are associated with 5HT receptors, including obesity, attention deficit disorder, migraine, depression, epilepsy, anxiety, Alzheimer's disease, withdrawal from drug abuse, pain, schizophrenia, stress-related disorders, panic disorder, sleep disorders, phobias, obsessive compulsive disorder, post-traumatic-stress syndrome, immune system depression, stress-induced gastrointestinal dysfunction, stress-induced cardiovascular dysfunction, and sexual dysfunction.

Certain indole derivatives useful as leukotriene antagonists

A compound of the formula STR1 in which R1 is hydrogen, halo, C1-4 alkyl, C1-4 alkoxy, nitrile, optionally protected carboxy, optionally protected tetrazolyl, trihalomethyl, hydroxy-C1-4 alkyl, aldehydo, --CH2 Z, --CH=CH--Z or --CH2 CH2 Z where Z is optionally protected carboxy or optionally protected tetrazolyl; R2 is halo, nitrile, an optionally protected acid group or --CONR7 R8 where R7 and R8 are each hydrogen or C1-4 alkyl; R3 and R4 are each hydrogen, C1-4 alkyl, optionally substituted phenyl, or C1-4 alkyl substituted by --CONR7 R8 or an optionally protected acid group; R5 is STR2 where W is --CH=CH--, --CH=N--, --N=CH--, --O-- or --S--, R9 is hydrogen, halo, C1-4 alkyl, C1-4 alkoxy or trihalomethyl, and R10 is hydrogen, C1-4 alkyl, C2-6 alkenyl, C3-6 cycloalkyl or C1-4 alkyl-C3-6 cycloalkyl; R6 is hydrogen or C1-4 alkyl; X is --O--(CH2)n CR11 R12, --CR11 R12 --, --CR11 R12.(CH2)n.CR13 R14 -- or --CR11 =CR12 -- where R11, R12, R13 and R14 are each hydrogen or C1-4 alkyl, and n is 0, 1 or 2; and Y is --O--CR15 R16 --, --CR15 =CR16 -- or --CR15 R16.CR17 R18 -- where R15, R16, R17 and R18 are each hydrogen or C 1-4 alkyl; or a salt thereof. The compounds in unprotected form are active as leukotriene antagonists.