7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester

Base Information

Chemical Name:7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester
CAS No.:182137-48-0
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester

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Chemical Property of 7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester

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Technology Process of 7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester

There total 1 articles about 7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 182137-38-8
(2S,5R)-5-(2-Bromo-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 182137-48-0
7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran;
DOI:10.1021/jo960759m

Reference yield:

: 182137-48-0
7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester

: (R)-1-(N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxamidyl)-4-guanidinobutyl-1-boronic acid pinenediol ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂ / Pd/C / methanol / 1.5 h / 20 °C / 760.05 Torr

2.1: 0.80 g / N-methylmorpholine / diethyl ether / 0.5 h / 0 °C

3.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 20 °C

4.1: BOPCl; triethylamine / dimethylformamide / 0.5 h / 0 °C

4.2: 38 percent / triethylamine / dimethylformamide / 18 h / 20 °C

5.1: 91 percent / sodium azide / dimethylformamide / 5 h / 100 °C

6.1: 31 percent / H₂ / Pd/C / ethyl acetate / 16 h / 20 °C / 760.05 Torr

7.1: 23 percent / dimethylaminopyridine / ethanol / 3 h / 80 °C

With 4-methyl-morpholine; dmap; sodium azide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol990294x

Reference yield:

: 182137-48-0
7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester

: 255841-22-6
t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 1.5 h / 20 °C / 760.05 Torr

2: 0.80 g / N-methylmorpholine / diethyl ether / 0.5 h / 0 °C

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1021/ol990294x