t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate

Base Information

• Chemical Name: t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate
• CAS No.: 255841-22-6
• Molecular Formula: C₂₀H₂₇NO₃
• Molecular Weight: 329.439
• Mol file: 255841-22-6.mol

Synonyms:t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate

Chemical Property of t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate

There total 2 articles about t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester (182137-48-0) → t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate (255841-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 1.5 h / 20 °C / 760.05 Torr

2: 0.80 g / N-methylmorpholine / diethyl ether / 0.5 h / 0 °C

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In methanol; diethyl ether;

DOI:10.1021/ol990294x

Reference yield:

hydrocinnamic acid chloride (645-45-4) + tert-butyl 7-azabicyclo[2.2.1 ]heptane-1-carboxylate (182137-45-7) → t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate (255841-22-6)

Guidance literature:

With 4-methyl-morpholine; In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1021/ol990294x

Reference yield: 100.0%

t-butyl N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylate (255841-22-6) → N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid (255841-23-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1021/ol990294x

upstream raw materials:

hydrocinnamic acid chloride

tert-butyl 7-azabicyclo[2.2.1 ]heptane-1-carboxylate

7-(benzyloxycarbonyl)-1-carboxy-7-azabicyclo[2.2.1]heptane tert-butyl ester

Downstream raw materials:

N-(3-phenylpropionyl)-7-azabicyclo[2.2.1]heptane-1-carboxylic acid