O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate

Base Information

Chemical Name:O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate
CAS No.:1504578-45-3
Molecular Formula:C₃₄H₄₀N₅O₁₆P
Molecular Weight:805.689
Hs Code.:

Synonyms:O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate

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Chemical Property of O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate

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Technology Process of O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate

There total 2 articles about O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: diammonium (4-methoxycarbonylphenylaminocarbonyl)methylphosphonate

: 52474-37-0
3'-O-acetyl-2'-deoxy-α-D-thymidine

: 1504578-45-3
O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate

: ammonium O-(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate

Guidance literature:: diammonium (4-methoxycarbonylphenylaminocarbonyl)methylphosphonate; 3'-O-acetyl-2'-deoxy-α-D-thymidine; With pyridine; dicyclohexyl-carbodiimide; at 37 ℃; for 12h;

With ammonium bicarbonate; In ethanol; water;
DOI:10.1134/S1068162013060058

Reference yield:

: 1116091-41-8
O,O'-diethyl [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate

: 1504578-45-3
O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl bromide / N,N-dimethyl-formamide / 12 h / 5 °C

1.2: DEAE cellulose

2.1: dicyclohexyl-carbodiimide; pyridine / 12 h / 37 °C

2.2: DEAE cellulose

With pyridine; trimethylsilyl bromide; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1134/S1068162013060058