(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid

Base Information

Chemical Name:(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid
CAS No.:1562404-70-9
Molecular Formula:C₄₆H₄₆N₄O₅
Molecular Weight:734.895
Hs Code.:

Synonyms:(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid

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Chemical Property of (2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid

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Technology Process of (2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid

There total 15 articles about (2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562404-94-7
(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid benzyl ester

: 1562404-70-9
(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In ethyl acetate; at 23 ℃; Inert atmosphere;

Reference yield:

: 146984-22-7
1-trityl-1H-1,2,3-triazole-4-carboxylic acid

: 1562404-70-9
(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1.5 h / 0 - 23 °C

2.1: hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon / ethyl acetate / 23 °C / Inert atmosphere

With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 76-83-5
trityl chloride

: 1562404-70-9
(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / N,N-dimethyl-formamide / 24 h / 0 - 23 °C

2.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / 0 °C

2.2: 1.5 h / 0 - 23 °C

3.1: hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon / ethyl acetate / 23 °C / Inert atmosphere

With pyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;