2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde

Base Information

Chemical Name:2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde
CAS No.:217652-47-6
Molecular Formula:C₂₄H₂₆O₂Si
Molecular Weight:374.555
Hs Code.:

Synonyms:2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde

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Chemical Property of 2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde

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Technology Process of 2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde

There total 5 articles about 2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 2-[3-(2-Ethynyl-phenyl)-3-hydroxy-prop-1-ynyl]-benzaldehyde

: 217652-47-6
2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1055/s-1998-1922

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 217652-47-6
2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / Ambient temperature

2: Pd-catalyst

3: CsF, NaHCO₃, Ac₂O

With 1H-imidazole; acetic anhydride; sodium hydrogencarbonate; cesium fluoride; Pd-catalyst; In N,N-dimethyl-formamide;
DOI:10.1055/s-1998-1922

Reference yield:

: 2-[3-Hydroxy-3-(2-iodo-phenyl)-prop-1-ynyl]-benzaldehyde

: 217652-47-6
2-[3-(tert-Butyl-dimethyl-silanyloxy)-3-(2-ethynyl-phenyl)-prop-1-ynyl]-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / Ambient temperature

2: Pd-catalyst

3: CsF, NaHCO₃, Ac₂O

With 1H-imidazole; acetic anhydride; sodium hydrogencarbonate; cesium fluoride; Pd-catalyst; In N,N-dimethyl-formamide;
DOI:10.1055/s-1998-1922