5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one

Base Information

• Chemical Name: 5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one
• CAS No.: 1589517-86-1
• Molecular Formula: C₁₉H₂₇FN₂OS₂
• Molecular Weight: 382.567

Synonyms:5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one

Chemical Property of 5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one

Chemical Property:

Purity/Quality:

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Technology Process of 5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one

There total 2 articles about 5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(4-fluorophenylmethyl)piperazine (70931-28-1) + thioctic acid-N-hydroxysuccinimide ester (40846-94-4) → 5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one (1589517-86-1)

Guidance literature:

In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.5012/bkcs.2013.34.11.3322

Reference yield:

1-(4-fluorophenylmethyl)piperazine (70931-28-1) + Thioctic acid (1077-28-7,62-46-4) → 5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one (1589517-86-1)

Guidance literature:

Thioctic acid; With dicyclohexyl-carbodiimide; In dichloromethane; for 0.166667h; Inert atmosphere;

1-(4-fluorophenylmethyl)piperazine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.05.045

Reference yield:

5-(1,2-dithiolan-3-yl)-1-(4-(4-fluorobenzyl)piperazin-1-yl)pentan-1-one (1589517-86-1) → 5-(1,2-dithiolan-3-yl)-1-[4-(4-fluorobenzyl)piperazin-1-yl]pentan-1-one chloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Inert atmosphere;

DOI:10.1016/j.bmc.2016.05.045

upstream raw materials:

1-(4-fluorophenylmethyl)piperazine

thioctic acid-N-hydroxysuccinimide ester

Thioctic acid

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