[5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid

Base Information

• Chemical Name: [5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid
• CAS No.: 1026924-30-0
• Molecular Formula: C₁₉H₁₄ClF₂N₃O₃
• Molecular Weight: 405.788

Synonyms:[5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid

Chemical Property of [5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid

Chemical Property:

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Technology Process of [5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid

There total 3 articles about [5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid benzyl ester (1026196-71-3) → [5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid (1026924-30-0)

Guidance literature:

With potassium hydroxide; at 20 ℃; for 3h;

DOI:10.1021/jm030131l

Reference yield:

benzaldehyde (100-52-7) → [5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid (1026924-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: CH₂Cl₂

1.2: 1,2-dichloro-benzene

2.1: acetonitrile / 70 °C

3.1: aq. KOH / 3 h / 20 °C

With potassium hydroxide; In dichloromethane; acetonitrile;

DOI:10.1021/jm030131l

Reference yield:

2-(3,5-dichloro-2-oxo-6-phenylpyrazin-1(2H)-yl)acetic acid benzyl ester (308845-81-0) → [5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid (1026924-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 70 °C

2: aq. KOH / 3 h / 20 °C

With potassium hydroxide; In acetonitrile;

DOI:10.1021/jm030131l

upstream raw materials:

[5-chloro-3-(2,5-difluoro-benzylamino)-2-oxo-6-phenyl-2H-pyrazin-1-yl]-acetic acid benzyl ester

benzaldehyde

2-(3,5-dichloro-2-oxo-6-phenylpyrazin-1(2H)-yl)acetic acid benzyl ester

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