9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

Base Information

Chemical Name:9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol
CAS No.:1353007-16-5
Molecular Formula:C₃₃H₄₀F₉NO₃S
Molecular Weight:701.737
Hs Code.:

9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

Synonyms:9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

There total 6 articles about 9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1353008-58-8
9-(6-bromohexyl)-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

: 1353009-22-9
N-(2,2-difluoroethyl)-3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propan-1-amine

: 1353007-16-5
9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

Guidance literature:: In acetonitrile; at 200 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 199730-54-6
3-chloropropyl 4,4,5,5,5-pentafluoropentyl sulphone

: 1353007-16-5
9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 72 h / 60 °C

2: acetonitrile / 0.25 h / 200 °C / Microwave irradiation

With sodium hydroxide; In ethanol; acetonitrile;

Reference yield:

: 209325-64-4
4,4,5,5,5-pentafluoropentyl-4-methylbenzene sulphonate

: 1353007-16-5
9-{6-[(2,2-difluoroethyl){3-[(4,4,5,5,5-pentafluoropentyl)sulphonyl]propyl}amino]hexyl}-4-fluoro-8-(4-fluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium thioacetate / acetone / Reflux

2: sodium methylate / methanol / 0.5 h / 20 °C / Cooling with ice

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 10 - 20 °C / Cooling with ice

4: sodium hydroxide / ethanol / 72 h / 60 °C

5: acetonitrile / 0.25 h / 200 °C / Microwave irradiation

With sodium methylate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; potassium thioacetate; In methanol; ethanol; chloroform; acetone; acetonitrile;