(2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate

Base Information Edit

Chemical Name:(2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate
CAS No.:171192-72-6
Molecular Formula:C₁₄H₁₉NO₃
Molecular Weight:249.31
Hs Code.:
Mol file:171192-72-6.mol

(2R,4R)-ethyl N<sup>1</sup>-benzyl-4-hydroxypyrrolidine-2-carboxylate

Synonyms:(2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate

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Chemical Property of (2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate Edit

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Technology Process of (2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate

There total 13 articles about (2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 77449-99-1
(2R,4R)-2-ethoxycarbonyl-4-hydroxypyrrolidine hydrochloride

: 100-39-0
benzyl bromide

: 171192-72-6
(2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: (2R,4R)-2-ethoxycarbonyl-4-hydroxypyrrolidine hydrochloride; benzyl bromide; With triethylamine; In chloroform; for 6h; Heating;

With sodium hydroxide; In chloroform; at 20 ℃;
DOI:10.1016/j.tetasy.2003.08.019

Reference yield: 78.0%

: (S)-ethyl 2-(benzyl(oxiran-2-ylmethyl)amino)acetate

: 171192-72-6
(2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: (S)-ethyl 2-(benzyl(oxiran-2-ylmethyl)amino)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -60 - -15 ℃; for 0.166667h;

With magnesium bromide ethyl etherate; In tetrahydrofuran; at -60 - 25 ℃; for 3.5h; Reagent/catalyst; diastereoselective reaction;
DOI:10.1016/j.tetlet.2015.03.119

Reference yield:

: ethyl (S)-N-benzyl-N-(3-chloro-2-hydroxypropyl)glycinate

: 171192-72-6
(2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In N,N-dimethyl-formamide; at -58 - 50 ℃; for 4.66667h; diastereoselective reaction;
DOI:10.1016/j.tetlet.2015.03.119