3-Amino-2-hydroxyhexanoic acid

Base Information

Chemical Name:3-Amino-2-hydroxyhexanoic acid
CAS No.:166196-05-0
Molecular Formula:C6H13 N O3
Molecular Weight:147.17
Hs Code.:2922509090
Mol file:166196-05-0.mol

Synonyms:3-Amino-2-hydroxyhexanoic acid

Suppliers and Price of 3-Amino-2-hydroxyhexanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-AMINO-2-HYDROXYHEXANOIC ACID 95.00%
5MG
$ 503.09

Total 6 raw suppliers

Chemical Property of 3-Amino-2-hydroxyhexanoic acid

Chemical Property:

Boiling Point:337.0±27.0 °C(Predicted)
PKA:3.04±0.32(Predicted)
PSA：83.55000
Density:1.185
LogP:0.25960

Purity/Quality:

99% ^*data from raw suppliers

3-AMINO-2-HYDROXYHEXANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Amino-2-hydroxyhexanoic acid

There total 1 articles about 3-Amino-2-hydroxyhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 367258-42-2
2-hydroxy-3-nitrohexanoic acid

: 166196-05-0,160801-76-3,160801-75-2,75638-60-7,75638-59-4
3-amino-2-hydroxyhexanoic acid

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; under 3051.17 - 3102.89 Torr;
DOI:10.1021/jm0489556 DOI:10.1021/jm060077j

Reference yield:

: 166196-05-0,160801-76-3,160801-75-2,75638-60-7,75638-59-4
3-amino-2-hydroxyhexanoic acid

: 367259-52-7
[2-(3-tert-butoxycarbonylamino-2-hydroxy-hexanoylamino)-acetylamino]-phenyl-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaOH / dioxane / 0.17 h / 0 °C

1.2: 89 percent / dioxane; H₂O / 1 h / 0 - 20 °C

2.1: 95 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

3.1: 98 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

4.1: 80 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050520a

Reference yield:

: 166196-05-0,160801-76-3,160801-75-2,75638-60-7,75638-59-4
3-amino-2-hydroxyhexanoic acid

: ({2-[(3-amino-2-hydroxyhexanoyl)amino]acetyl}amino)(phenyl)acetic acid tert-butyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. NaOH / dioxane / 0.17 h / 0 °C

1.2: 89 percent / dioxane; H₂O / 1 h / 0 - 20 °C

2.1: 95 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

3.1: 98 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

4.1: 80 percent / 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-methylmorpholine / dimethylformamide; CH₂Cl₂ / -20 °C

5.1: 100 percent / HCl / dioxane; ethyl acetate / 0.25 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm050520a