N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine

Base Information

Chemical Name:N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine
CAS No.:1472068-36-2
Molecular Formula:C₂₁H₁₅F₂NO₃
Molecular Weight:367.352
Hs Code.:

Synonyms:N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine

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Technology Process of N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine

There total 1 articles about N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 4397-53-9
p-benzyloxybenzaldehyde

: 1544-85-0
2,2-difluoro-benzo[1,3]dioxol-5-ylamine

: 1472068-36-2
N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine

Guidance literature:: With toluene-4-sulfonic acid; In ethanol; for 1h; Reflux;
DOI:10.1002/cmdc.201300015

Reference yield: 96.0%

: 1472068-36-2
N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine

: 1472068-38-4
(4-benzyloxybenzyl)-(2,2-difluorobenzo[1,3]dioxol-5-yl)amine

Guidance literature:: With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 18h;
DOI:10.1002/cmdc.201300015

Reference yield:

: 1472068-36-2
N-(E)-{[4-(benzyloxy)phenyl]methylidene}-2,2-difluoro-2H-1,3-benzodioxol-5-amine

: 1472068-41-9
N-(4-benzyloxybenzyl)-N-(2,2-difluorobenzo[1,3]dioxol-5-yl)hydrazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate; ethanol / 18 h / 0 - 20 °C

2.1: sodium nitrite; sulfuric acid / chloroform; water / 1 h / 0 °C

2.2: 20 °C

With sodium tetrahydroborate; ethanol; sulfuric acid; sodium nitrite; In chloroform; water;
DOI:10.1002/cmdc.201300015