Methanesulfonohydrazide

Base Information

• Chemical Name: Methanesulfonohydrazide
• CAS No.: 10393-86-9
• Molecular Formula: CH6N2O2S
• Molecular Weight: 110.137
• Hs Code.: 2935009090
• NSC Number: 109925
• DSSTox Substance ID: DTXSID80296565
• Nikkaji Number: J1.259.121G
• Wikidata: Q82037220
• Mol file: 10393-86-9.mol

Synonyms:methanesulfonohydrazide;10393-86-9;methanesulfonyl hydrazide;Methanesulfonic acid hydrazide;n-methanesulfonylhydrazine;Methanesulfonic acid,hydrazide;METHANESULFONYLHYDRAZIDE;Methanesulfonic acid, hydrazide;NSC109925;Methanesulfonylhydrazine;methanesulfono-hydrazide;CH3SO2NHNH2;CH6N2O2S;SCHEMBL109558;DTXSID80296565;VKHZYWVEBNIRLX-UHFFFAOYSA-N;BCP10418;MFCD00047816;AKOS000163048;AM85458;CS-W022771;NSC-109925;BS-10012;SY106480;FT-0628292;EN300-105246;A800854;Z283687760

Chemical Property of Methanesulfonohydrazide

Chemical Property:

• Vapor Pressure: 0.0711mmHg at 25°C
• Melting Point: 46-48 °C
• Refractive Index: 1.491
• Boiling Point: 229 °C at 760 mmHg
• PKA: 9.55±0.40(Predicted)
• Flash Point: 92.3 °C
• PSA: 80.57000
• Density: 1.401 g/cm³
• LogP: 0.58130
• Sensitive.: Moisture Sensitive
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 110.01499861
• Heavy Atom Count: 6
• Complexity: 108

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methanesulfonohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 15-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)NN

Technology Process of Methanesulfonohydrazide

There total 3 articles about Methanesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanesulfonyl chloride (124-63-0) → methanesulphonyl hydrazide (10393-86-9)

Guidance literature:

With sodium hydroxide; hydrazine hydrate; In water; at 8 ℃;

DOI:10.1002/hlca.19890720627

Reference yield:

methanesulfonyl chloride (124-63-0) → methanesulphonyl hydrazide (10393-86-9) + di-methanesulfonyl hydrazide (18300-37-3)

Guidance literature:

With sodium hydroxide; hydrazine hydrate; In water; cooling;

DOI:10.1016/j.tet.2005.08.110

Reference yield:

→ methanesulphonyl hydrazide (10393-86-9)

Guidance literature:

upstream raw materials:

methanesulfonyl chloride

Downstream raw materials:

N'-trans-cinnamylidene-N-methanesulfonyl-N-trichloromethanesulfenyl-hydrazine

methanesulfonic acid cyclohexylidenehydrazide

N^β-<4-Chlorphenoxycarbimidoyl>-methansulfonsaeurehydrazid

N^β-<3-Chlorphenoxy-carbamidoyl>-methansulfonsaeure-hydrazid

Refernces

• 1、 Gündüzalp, Ayla Balaban,Parlakgümü?, G?khan,Uzun, Demet,?zmen, ümmuhan ?zdemir,?zbek, Neslihan,Sari, Musa,Tun?, Tuncay. "Carbonic anhydrase inhibitors: Synthesis, characterization and inhibition activities of furan sulfonylhydrazones against carbonic anhydrase i (hCA I)". . p. 332 - 340. Retrieved 2016.
• 2、 Ozdemir, Ummuhan O.,Ilbiz, Firdevs,Balaban Gunduzalp, Ayla,Ozbek, Neslihan,Karagoz Gen?, Zuhal,Hamurcu, Fatma,Tekin, Suat. "Alkyl sulfonic acide hydrazides: Synthesis, characterization, computational studies and anticancer, antibacterial, anticarbonic anhydrase II (hCA II) activities". . p. 464 - 474. Retrieved 2015.
• 3、 Rong, Xiaona,Guo, Jingwen,Hu, Zheqi,Huang, Lehao,Gu, Yugui,Cai, Yuepiao,Liang, Guang,Xia, Qinqin. "Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives". supporting information. p. 701 - 708. Retrieved 2020/12/30.
• 4、 Das, Sanju,De Sarkar, Suman,Mandal, Tanumoy. "Acridine Orange Hemi(Zinc Chloride) Salt as a Lewis Acid-Photoredox Hybrid Catalyst for the Generation of α-Carbonyl Radicals". supporting information. . Retrieved 2021/12/10.