Technology Process of N-((7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)cyclobutanesulfonamide
There total 7 articles about N-((7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)cyclobutanesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere; Cooling with ice
2: triethylamine / N,N-dimethyl-formamide; ethyl acetate; n-heptane / 3 h / 20 °C
3: triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
4: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere
5: hydrogen; ammonia / tetrahydrofuran; methanol / 20 °C / 760.05 Torr
6: triethylamine / dichloromethane / 0 °C
7: trifluoroacetic acid / dichloromethane / 20 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); ammonia; hydrogen; boron tribromide; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / N,N-dimethyl-formamide; ethyl acetate; n-heptane / 3 h / 20 °C
2: triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
3: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere
4: hydrogen; ammonia / tetrahydrofuran; methanol / 20 °C / 760.05 Torr
5: triethylamine / dichloromethane / 0 °C
6: trifluoroacetic acid / dichloromethane / 20 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); ammonia; hydrogen; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
