Technology Process of N-((8-benzyl-7-(3-cyanooxetan-3-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)cyclobutanesulfonamide
There total 8 articles about N-((8-benzyl-7-(3-cyanooxetan-3-ylamino)-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)cyclobutanesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
oxetan-3-one; N-((7-amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)cyclobutanesulfonamide;
at 200 ℃;
for 0.0333333h;
Sealed tube;
trimethylsilyl cyanide;
at 200 ℃;
for 0.0333333h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / N,N-dimethyl-formamide; ethyl acetate; n-heptane / 3 h / 20 °C
2.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
3.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere
4.1: hydrogen; ammonia / tetrahydrofuran; methanol / 20 °C / 760.05 Torr
5.1: triethylamine / dichloromethane / 0 °C
6.1: trifluoroacetic acid / dichloromethane / 20 °C
7.1: 0.03 h / 200 °C / Sealed tube
7.2: 0.03 h / 200 °C / Sealed tube
With
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); ammonia; hydrogen; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere
3.1: hydrogen; ammonia / tetrahydrofuran; methanol / 20 °C / 760.05 Torr
4.1: triethylamine / dichloromethane / 0 °C
5.1: trifluoroacetic acid / dichloromethane / 20 °C
6.1: 0.03 h / 200 °C / Sealed tube
6.2: 0.03 h / 200 °C / Sealed tube
With
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); ammonia; hydrogen; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
