Technology Process of 7-{4'-[4-(p-nitrophenylethynyl)benzoyl]but-3'-en-1'-yl}-3-methoxyestra-1,3,5(10),6-tetraene-17-one-17,17-(2''-[5'',5''-dimethyl-1'',3''-dioxane])
There total 9 articles about 7-{4'-[4-(p-nitrophenylethynyl)benzoyl]but-3'-en-1'-yl}-3-methoxyestra-1,3,5(10),6-tetraene-17-one-17,17-(2''-[5'',5''-dimethyl-1'',3''-dioxane]) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzoic acid;
In
benzene;
for 12h;
Heating;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: KOH / dimethylsulfoxide
2: p-TsOH / benzene
3: 55 percent / KMnO4; Adegon 464 / benzene
4: 47 percent / [PhCH2N(CH3)3]OH / dioxane; H2O / 18 h / 50 °C
5: 30 percent / ethanol / 2.5 h / Heating
6: 36 percent / t-BuOK / diethyl ether / 150 °C
7: 65 percent / DIBAL-H / CH2Cl2; toluene / 6.5 h / -78 - 20 °C
8: 61 percent / C6H5CO2H / benzene / 12 h / Heating
With
potassium hydroxide; potassium permanganate; Adegon 464; potassium tert-butylate; N-benzyl-trimethylammonium hydroxide; diisobutylaluminium hydride; toluene-4-sulfonic acid; benzoic acid;
In
1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;
4: Michael addition / 8: Wittig olefination;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: p-TsOH / benzene
2: 55 percent / KMnO4; Adegon 464 / benzene
3: 47 percent / [PhCH2N(CH3)3]OH / dioxane; H2O / 18 h / 50 °C
4: 30 percent / ethanol / 2.5 h / Heating
5: 36 percent / t-BuOK / diethyl ether / 150 °C
6: 65 percent / DIBAL-H / CH2Cl2; toluene / 6.5 h / -78 - 20 °C
7: 61 percent / C6H5CO2H / benzene / 12 h / Heating
With
potassium permanganate; Adegon 464; potassium tert-butylate; N-benzyl-trimethylammonium hydroxide; diisobutylaluminium hydride; toluene-4-sulfonic acid; benzoic acid;
In
1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; toluene; benzene;
3: Michael addition / 7: Wittig olefination;
![7-(2'-formylethyl)-3-methoxyestra-1,3,5<sup>(10)</sup>,6-tetraene-17-one-17,17-(2''-[5'',5''-dimethyl-1'',3''-dioxane])](/Databaselist/images/loading.webp)
