N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

Base Information

Chemical Name:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide
CAS No.:847165-22-4
Molecular Formula:C₄₁H₅₀N₆O₇
Molecular Weight:738.884
Hs Code.:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

Synonyms:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

Suppliers and Price of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

There total 4 articles about N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 109772-44-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoic acid

: 847165-46-2
H-Gly-Aib-Aib-N(Me)Ph

: 847165-22-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; at 20 ℃;
DOI:10.1002/hlca.200490275

Reference yield:

: Z-Gly-Aib-Aib-N(Me)Ph

: 847165-22-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / methanol

2: 69 percent / PyBOP; N-ethyl-diisopropylamine / CH₂Cl₂; acetonitrile / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1002/hlca.200490275

Reference yield:

: 71989-31-6
Fmoc-Pro-OH

: 847165-22-4
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-2-amino-2-methylpropanoylglycyl-2-amino-2-methylpropanoyl-2-amino-N,2-dimethyl-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / tetrahydrofuran / 60 h / 20 °C

2: 74 percent / aq. HCl / acetonitrile / 20 °C

3: 69 percent / PyBOP; N-ethyl-diisopropylamine / CH₂Cl₂; acetonitrile / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/hlca.200490275