{3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester
• CAS No.: 1085940-97-1
• Molecular Formula: C₂₉H₃₆N₆O₃
• Molecular Weight: 516.643
• Mol file: 1085940-97-1.mol

Synonyms:{3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester

Chemical Property of {3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester

There total 10 articles about {3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyl-2-(1-bromo-2-methyl-propyl)-3H-benzo[g]pteridin-4-one (1085940-96-0) + N-Boc-1,3-diaminopropane (75178-96-0) → {3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester (1085940-97-1)

Guidance literature:

at 70 ℃; for 0.5h;

Reference yield:

2-carbomethoxy-3-hydroxyquinoxaline (21580-62-1) → {3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester (1085940-97-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: trichlorophosphate / 3 h / Heating / reflux

1.2: 1 h / pH 7 - 8

2.1: ammonia / water / 60 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0 - 60 °C

4.1: sodium hydroxide / ethanol; water / 1 h / 20 °C

5.1: potassium carbonate / acetonitrile / 2 h / 60 °C

6.1: bromine; sodium acetate / acetic acid / 1 h / 40 °C

7.1: 0.5 h / 70 °C

With sodium hydroxide; ammonia; bromine; sodium acetate; potassium carbonate; triethylamine; trichlorophosphate; In ethanol; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2-isobutylbenzo[g]pteridin-4(3H)-one (1085940-94-8) → {3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester (1085940-97-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 2 h / 60 °C

2: bromine; sodium acetate / acetic acid / 1 h / 40 °C

3: 0.5 h / 70 °C

With bromine; sodium acetate; potassium carbonate; In acetic acid; acetonitrile;

upstream raw materials:

3-benzyl-2-(1-bromo-2-methyl-propyl)-3H-benzo[g]pteridin-4-one

N-Boc-1,3-diaminopropane

2-carbomethoxy-3-hydroxyquinoxaline

2-Amino-3-carboxamidoquinoxaline

Downstream raw materials:

C₃₇H₄₂N₆O₄