4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide
CAS No.:1380656-47-2
Molecular Formula:C₃₃H₂₇F₂N₃O₅
Molecular Weight:583.591
Hs Code.:

Synonyms:4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

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Technology Process of 4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

There total 8 articles about 4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.6%

: 1217340-22-1
5-(4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

: 3-(pyridin-2-yl)oxetan-3-amine dihydrochloride

: 1380656-47-2
4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1217340-75-4
4-fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl trifluoromethanesulfonate

: 1380656-47-2
4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 - 95 °C

2: sodium hydroxide / tetrahydrofuran; methanol / 24 h / 20 °C / Inert atmosphere

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 691856-86-7
ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate

: 1380656-47-2
4-fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(3-pyridin-2-yloxetan-3-ylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: Selectfluor / acetonitrile / 20 h / 20 °C / Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 100 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 16 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0 - 20 °C

5: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 - 95 °C

6: sodium hydroxide / tetrahydrofuran; methanol / 24 h / 20 °C / Inert atmosphere

7: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; caesium carbonate; Selectfluor; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;