2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid

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Chemical Name:2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid
CAS No.:245736-64-5
Molecular Formula:C₄₅H₆₅NO₁₃
Molecular Weight:828.01
Hs Code.:

2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid

Synonyms:2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid

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Chemical Property of 2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid

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Technology Process of 2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid

There total 1 articles about 2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 245736-63-4
2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid benzyl ester

: 245736-64-5
2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid

Guidance literature:: With cyclohexa-1,4-diene; palladium on activated charcoal; In ethanol;
DOI:10.1021/ja990789h

Reference yield: 96.0%

: 245736-64-5
2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid

: 245736-65-6
C₄₅H₆₃NO₁₂

Guidance literature:: With dmap; 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine; In benzene;
DOI:10.1021/ja990789h

Reference yield:

: 245736-64-5
2-{6-[4-hydroxy-9-{3-[4-hydroxy-3-methyl-6-(2-methyl-propenyl)-tetrahydro-pyran-2-ylmethyl]-isoxazol-5-yl}-1-(4-methoxy-benzyloxy)-5-methyl-6-oxo-decyl]-2-methoxy-4-methoxycarbonylmethylene-tetrahydro-pyran-2-yl}-propionic acid

: [(Z)-(1S,4S,5S,9R,10R,13R,14R,18R,23S,25S,27R)-21-Amino-5,13-dihydroxy-10-(4-methoxy-benzyloxy)-4,14,18,27-tetramethyl-25-(2-methyl-propenyl)-3,15,19-trioxo-2,24,28-trioxa-tricyclo[21.3.1.1^5,9]octacos-20-en-(7E)-ylidene]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 2,4,6-Cl₃PhCOCl, i-Pr₂NEt, DMAP / benzene

2: 99 percent / aq. TsOH / acetonitrile

3: 74 percent / H₂ / W-2 Raney Ni / ethanol; acetic acid / 760 Torr

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; W-2 Raney Ni; In ethanol; acetic acid; acetonitrile; benzene;
DOI:10.1021/ja990789h