1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene

Base Information

Chemical Name:1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene
CAS No.:691881-05-7
Molecular Formula:C₁₈H₂₄N₂O₄S
Molecular Weight:364.466
Hs Code.:

Synonyms:1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene

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Chemical Property of 1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene

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Technology Process of 1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene

There total 4 articles about 1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 691881-04-6
3-cyclohexyl-1-(2-hydroxyethyl)-4-(4-methylthiophenyl)pyrazol-5-ol

: 691881-05-7
1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene

Guidance literature:: With oxone; In methanol; water; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 70290-37-8
(4-methylsulfanyl-phenyl)-acetic acid methyl ester

: 691881-05-7
1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 99 percent / tetrahydrofuran / 2 h / -78 - 0 °C

2.1: 46 percent / glacial AcOH / 1 h / 100 °C

3.1: 43 percent / Oxone(R) / methanol; H₂O / 0.5 h / 20 °C

With oxone; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 16188-55-9
2-(4-(methylthio)phenyl)acetic acid

: 691881-05-7
1-[3-cyclohexyl-5-hydroxy-1-(2-hydroxyethyl)-pyrazol-4-yl]-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / H₂SO₄ / 16 h / 50 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

2.2: 99 percent / tetrahydrofuran / 2 h / -78 - 0 °C

3.1: 46 percent / glacial AcOH / 1 h / 100 °C

4.1: 43 percent / Oxone(R) / methanol; H₂O / 0.5 h / 20 °C

With oxone; sulfuric acid; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2004.01.012