6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester

Base Information

Chemical Name:6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester
CAS No.:847039-37-6
Molecular Formula:C₂₇H₃₅FN₂O₅
Molecular Weight:486.584
Hs Code.:

Synonyms:6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester

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Chemical Property of 6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester

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Technology Process of 6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester

There total 1 articles about 6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 847039-35-4
6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-hydroxy-hexanoic acid methyl ester

: 74-88-4
methyl iodide

: 847039-37-6
6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester

Guidance literature:: 6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-hydroxy-hexanoic acid methyl ester; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.5h;

methyl iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;

Reference yield: 83.0%

: 847039-37-6
6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester

: 847039-38-7
6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbonyl]-2S-methoxy-hexanoic acid

Guidance literature:: 6-(4-ethoxy-phenyl)-3R-[4-(2-fluoro-phenyl)-piperazine-1-carbanoyl]-2S-methoxy-hexanoic acid methyl ester; With sodium hydroxide; In methanol; water; at 20 ℃; for 16h;

With hydrogenchloride; In methanol; water; pH=3;