Fmoc-(R)-3-amino-4-(4-bromo-phenyl)-butyric acid

Base Information

Chemical Name:Fmoc-(R)-3-amino-4-(4-bromo-phenyl)-butyric acid
CAS No.:331763-76-9
Molecular Formula:C₂₅H₂₂BrNO₄
Molecular Weight:480.358
Hs Code.:
Mol file:331763-76-9.mol

Synonyms:331763-76-9;Fmoc-(R)-3-amino-4-(4-bromo-phenyl)-butyric acid;Fmoc-(R)-3-amino-4-(4-bromophenyl)-butyric acid;(3R)-4-(4-bromophenyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic Acid;(R)-3-((((9H-Ffluoren-9-yl)methoxy)carbonyl)amino)-4-(4-bromophenyl)butanoic acid;Fmoc-4-bromo-D-beta-homophenylalanine;MFCD01860918;Fmoc-(S)-3-amino-4-(4-bromophenyl)butanoic acid;SCHEMBL22960738;AKOS025401939;FD10261;AC-27460;PS-12252;CS-0059677;EN300-817055;fmoc-(r)-3-amino-4-(4-bromophenyl)butyric acid;(3R)-4-(4-bromophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid;(R)-3-((((9H-Ffluoren-9-yl)methoxy)carbonyl)amino)-4-(4-bromophenyl)butanoicacid

Suppliers and Price of Fmoc-(R)-3-amino-4-(4-bromo-phenyl)-butyric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Fmoc-(R)-3-amino-4-(4-bromophenyl)-butyric acid
5g
$ 1952.00

Matrix Scientific
Fmoc-(R)-3-amino-4-(4-bromophenyl)-butyric acid
1g
$ 534.00

Crysdot
(R)-3-((((9H-Ffluoren-9-yl)methoxy)carbonyl)amino)-4-(4-bromophenyl)butanoicacid 95+%
1g
$ 525.00

ChemPep
Fmoc-D-β-HoPhe(4-Br)-OH
25g
$ 1746.00

ChemPep
Fmoc-D-β-HoPhe(4-Br)-OH
5g
$ 582.00

Chemenu
Fmoc-(R)-3-Amino-4-(4-bromophenyl)-butyricacid 95%
1g
$ 496.00

American Custom Chemicals Corporation
FMOC-(R)-3-AMINO-4-(4-BROMO-PHENYL)-BUTYRIC ACID 95.00%
5MG
$ 451.73

Ambeed
(R)-3-((((9H-Ffluoren-9-yl)methoxy)carbonyl)amino)-4-(4-bromophenyl)butanoicacid 98%
1g
$ 120.00

Ambeed
(R)-3-((((9H-Ffluoren-9-yl)methoxy)carbonyl)amino)-4-(4-bromophenyl)butanoicacid 98%
250mg
$ 48.00

Ambeed
(R)-3-((((9H-Ffluoren-9-yl)methoxy)carbonyl)amino)-4-(4-bromophenyl)butanoicacid 98%
100mg
$ 32.00

Total 15 raw suppliers

Chemical Property of Fmoc-(R)-3-amino-4-(4-bromo-phenyl)-butyric acid

Chemical Property:

PSA：75.63000
LogP:5.76450
Storage Temp.:2-8°C
XLogP3:5.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:479.07322
Heavy Atom Count:31
Complexity:599

Purity/Quality:

98%min ^*data from raw suppliers

Fmoc-(R)-3-amino-4-(4-bromophenyl)-butyric acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CC=C(C=C4)Br)CC(=O)O
Isomeric SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@H](CC4=CC=C(C=C4)Br)CC(=O)O

Technology Process of Fmoc-(R)-3-amino-4-(4-bromo-phenyl)-butyric acid

There total 6 articles about Fmoc-(R)-3-amino-4-(4-bromo-phenyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 270062-84-5,773045-17-3
(S)-3-Amino-4-(4-bromo-phenyl)-butyric acid

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 331763-76-9,270062-86-7
(S)-4-(4-bromophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid

Guidance literature:: With sodium carbonate; In water; acetone; at 20 ℃; for 10h;
DOI:10.1002/hlca.200690143

Reference yield:

: 911852-64-7
(S)-methyl 4-(4-bromophenyl)-3-{[(tert-butoxy)carbonyl]amino}butanoate

: 331763-76-9,270062-86-7
(S)-4-(4-bromophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NaOH / methanol; H₂O / 14 h / 20 °C

2: CF₃COOH / CH₂Cl₂ / 5 h / 20 °C

3: 990 mg / Na₂CO₃ / acetone; H₂O / 10 h / 20 °C

With sodium hydroxide; sodium carbonate; trifluoroacetic acid; In methanol; dichloromethane; water; acetone;
DOI:10.1002/hlca.200690143

Reference yield:

: 622865-15-0
(S)-3-{[(tert-butoxy)carbonyl]amino}-4-(4-bromophenyl)-1-diazobutan-2-one

: 331763-76-9,270062-86-7
(S)-4-(4-bromophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / AgCO₂CF₃ / H₂O; triethylamine / 18 h / 0 - 20 °C

2: 93 percent / NaOH / methanol; H₂O / 14 h / 20 °C

3: CF₃COOH / CH₂Cl₂ / 5 h / 20 °C

4: 990 mg / Na₂CO₃ / acetone; H₂O / 10 h / 20 °C

With sodium hydroxide; silver trifluoroacetate; sodium carbonate; trifluoroacetic acid; In methanol; dichloromethane; water; triethylamine; acetone; 1: Wolff rearrangement;
DOI:10.1002/hlca.200690143