ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate
CAS No.:1314127-91-7
Molecular Formula:C₂₂H₂₂N₂O₄
Molecular Weight:378.428
Hs Code.:

Synonyms:ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate

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Chemical Property of ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate

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Technology Process of ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate

There total 1 articles about ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 355391-05-8
4-(cyclopropylmethoxy)benzoic acid

: 71086-99-2
ethyl 5-amino-1H-indole-2-carboxylate

: 1314127-91-7
ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 43.0%

: 1314127-91-7
ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate

: 1314127-92-8
4-(cyclopropylmethoxy)-N-(2-formyl-1H-indol-5-yl)benzamide

Guidance literature:: ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate; With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 3h;

With manganese(IV) oxide; In 1,2-dimethoxyethane; at 70 ℃; Inert atmosphere;

Reference yield:

: 1314127-91-7
ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1H-indole-2-carboxylate

: 1314126-71-0
4-(cyclopropylmethoxy)-N-[2-({[(3-methyloxetan-3-yl)methyl]amino}methyl)-1H-indol-5-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -78 °C

1.2: 70 °C / Inert atmosphere

2.1: acetic acid / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h

2.2: 20 °C

With diisobutylaluminium hydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;