N-benzylcrinasiadine

Base Information

• Chemical Name: N-benzylcrinasiadine
• CAS No.: 62334-03-6
• Molecular Formula: C₂₁H₁₅NO₃
• Molecular Weight: 329.355
• Mol file: 62334-03-6.mol

Synonyms:N-benzylcrinasiadine

Chemical Property of N-benzylcrinasiadine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzylcrinasiadine

There total 9 articles about N-benzylcrinasiadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ N-benzylcrinasiadine (62334-03-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

Reference yield: 68.0%

5-benzyl-[1,3]dioxolo[4,5-j]phenanthridin-5-ium bromide → N-benzylcrinasiadine (62334-03-6)

Guidance literature:

With 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at -10 ℃; Green chemistry;

DOI:10.1039/c8gc01488d

Reference yield: 55.0%

carbon monoxide (201230-82-2) + N-benzyl-2-iodoaniline (76464-99-8) + 6-(trimethylsilyl)benzo[d][1,3]dioxol-5-yl triflate (717903-52-1) → N-benzylcrinasiadine (62334-03-6)

Guidance literature:

With palladium diacetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; cesium fluoride; In water; acetonitrile; at 100 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201508340

upstream raw materials:

5-benzyl-(4ar,11bt)-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

benzo[1,3]dioxole-5-carboxylic acid benzyl-cyclohex-1-enyl-amide

benzyl chloride

(4ar,11bt)-3,4a,5,11b-tetrahydro-4H-[1,3]dioxolo[4,5-j]phenanthridin-6-one