4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Base Information

• Chemical Name: 4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
• CAS No.: 900505-04-6
• Molecular Formula: C₃₀H₂₉Cl₂IN₂O₅
• Molecular Weight: 695.381
• Mol file: 900505-04-6.mol

Synonyms:4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Chemical Property of 4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

There total 10 articles about 4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorosalicylaldehyde (2420-26-0) → 4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (900505-04-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Cs₂CO₃ / tetrahydrofuran / 3 h / Heating

2: NaBH₄ / tetrahydrofuran / 2 h / 20 °C

3: SOCl₂ / CH₂Cl₂ / 1 h / 20 °C

4: Cs₂CO₃ / tetrahydrofuran / 80 °C

With sodium tetrahydroborate; thionyl chloride; caesium carbonate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2006.04.009

Reference yield:

2-allyloxy-4-chloro-1-chloromethylbenzene (900504-99-6) + 3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (900505-03-5) → 4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (900505-04-6)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; at 80 ℃;

DOI:10.1016/j.bmcl.2006.04.009

Reference yield:

2-(allyloxy)-4-chlorobenzaldehyde (787633-69-6) → 4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (900505-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / tetrahydrofuran / 2 h / 20 °C

2: SOCl₂ / CH₂Cl₂ / 1 h / 20 °C

3: Cs₂CO₃ / tetrahydrofuran / 80 °C

With sodium tetrahydroborate; thionyl chloride; caesium carbonate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2006.04.009

upstream raw materials:

2-allyloxy-4-chloro-1-chloromethylbenzene

3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

2-(allyloxy)-4-chlorobenzaldehyde

(2-(allyloxy)-4-chlorophenyl)methanol