1-benzyl-N²,N⁴-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide

Base Information

• Chemical Name: 1-benzyl-N²,N⁴-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide
• CAS No.: 1002555-77-2
• Molecular Formula: C₂₇H₂₃Cl₂N₃O₃
• Molecular Weight: 508.404

Synonyms:1-benzyl-N²,N⁴-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide

Chemical Property of 1-benzyl-N²,N⁴-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide

Chemical Property:

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Technology Process of 1-benzyl-N²,N⁴-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide

There total 3 articles about 1-benzyl-N²,N⁴-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C17H17ClN2O (77871-53-5) → 1-benzyl-N2,N4-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide (1002555-77-2)

Guidance literature:

With tert.-butylhydroperoxide; oxygen; copper(II) trifluoroacetate; trifluoroacetic acid; In acetonitrile; at 80 ℃; for 2h; under 760.051 Torr; Mechanism;

DOI:10.1021/ol4022222

Reference yield: 59.0%

3-(benzylamino)-N-(4-chlorophenyl)but-2-enamide → 1-benzyl-N2,N4-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide (1002555-77-2)

Guidance literature:

With trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1021/ol702362n

Reference yield:

4'-Chloroacetoacetanilide (101-92-8) + benzylamine (100-46-9) → 1-benzyl-N2,N4-bis(4-chlorophenyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide (1002555-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide / water / 12 h / 20 °C

2: copper(II) trifluoroacetate; tert.-butylhydroperoxide; trifluoroacetic acid; oxygen / acetonitrile / 2 h / 80 °C / 760.05 Torr

With tert.-butylhydroperoxide; tetrabutylammomium bromide; oxygen; copper(II) trifluoroacetate; trifluoroacetic acid; In water; acetonitrile;

DOI:10.1021/ol4022222

upstream raw materials:

C₁₇H₁₇ClN₂O

4'-Chloroacetoacetanilide

benzylamine

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