77871-53-5Relevant academic research and scientific papers
Cu(TFA)2-catalyzed oxidative tandem cyclization/1,2-alkyl migration of enamino amides for synthesis of pyrrolin-4-ones
Zhang, Zhi-Jing,Ren, Zhi-Hui,Wang, Yao-Yu,Guan, Zheng-Hui
supporting information, p. 4822 - 4825 (2013/10/08)
A novel Cu(TFA)2-catalyzed oxidative tandem cyclization/1,2- alkyl migration of readily available enamino amides for the synthesis of pyrrolin-4-ones has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the rapid synthesis of substituted pyrrolin-4-ones in high yields under mild conditions.
Synthesis of functionalized pyrroles via catalyst- and solvent-free sequential three-component enamine-azoene annulation
Attanasi, Orazio A.,Favi, Gianfranco,Mantellini, Fabio,Moscatelli, Giada,Santeusanio, Stefania
supporting information; experimental part, p. 2860 - 2866 (2011/05/30)
A new and efficient synthesis of polysubstituted pyrroles by a sequential one-pot three-component reaction between primary aliphatic amines, active methylene compounds, and 1,2-diaza-1,3-dienes (DDs) is reported. The reactions were performed without catalyst and under solvent-free conditions with complete control of pathway selectivity. Notably, the ready availability of the starting materials and the high level of practicability of the reaction and work up make this approach an attractive complementary method for access to unknown polysubstituted pyrroles.
