(R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride

Base Information

• Chemical Name: (R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride
• CAS No.: 1140496-10-1
• Molecular Formula: C₁₄H₁₇ClN₄*ClH
• Molecular Weight: 313.23

Synonyms:(R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride

Chemical Property of (R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride

Chemical Property:

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Technology Process of (R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride

There total 1 articles about (R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-tert-butyl 2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)pyrrolidine-1-carboxylate (1140495-89-1) → (R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride (1140496-10-1)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2010.07.082

Reference yield: 91.0%

(R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride (1140496-10-1) + 4-Trifluoromethylphenylacetic acid (32857-62-8) → (R)-1-(2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethanone (1140490-32-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 12h;

Reference yield: 87.0%

(R)-4-(4-chlorobenzyl)-3-methyl-5-(pyrrolidin-2-yl)-4H-1,2,4-trazole hydrochloride (1140496-10-1) + p-chlorphenylisocyanate (104-12-1) → (R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)-N-(4-chlorophenyl)pyrrolidine-1-carboxamide (1140490-16-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 12h;

upstream raw materials:

(R)-tert-butyl 2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)pyrrolidine-1-carboxylate

Downstream raw materials:

(R)-1-(2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethanone

(R)-3-(2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl)-4-(4-chloro-2-fluorophenylamino)cyclobut-3-ene-1,2-dione

(R)-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)-N-(4-chlorophenyl)pyrrolidine-1-carboxamide

(R)-4-chlorophenyl-2-(4-(4-chlorobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)pyrrolidine-1-carboxylate

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