Cbz-ΔTrp-OMe

Base Information

• Chemical Name: Cbz-ΔTrp-OMe
• CAS No.: 130680-69-2
• Molecular Formula: C₂₀H₁₈N₂O₄
• Molecular Weight: 350.374
• Mol file: 130680-69-2.mol

Synonyms:Cbz-ΔTrp-OMe

Chemical Property of Cbz-ΔTrp-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-ΔTrp-OMe

There total 4 articles about Cbz-ΔTrp-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-benzyloxycarbonyl-N'-(tert-butyloxycarbonyl)-Z-α,β-didehydrotryptophan (130680-70-5) → Cbz-ΔTrp-OMe (130680-69-2)

Guidance literature:

With lithium hydroxide; In methanol; Ambient temperature;

DOI:10.1248/cpb.38.2020

Reference yield: 30.0%

(S)-N-benzyloxycarbonyl-L-tryptophan methyl ester (2717-76-2,130812-44-1,130812-46-3) → Cbz-ΔTrp-OMe (130680-69-2)

Guidance literature:

With zirconium(IV) chloride; Nitrosobenzene; In toluene; at 0 - 20 ℃; for 2h;

DOI:10.1021/ja061660s

Reference yield:

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) → Cbz-ΔTrp-OMe (130680-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) 1M NaOH / 1) dioxane - water, 0 deg C, 20 min, 2) r.t., 5 d

2: 1) tert-BuOK / 1) CH₂Cl₂, -70 deg C, 2) CH₂Cl₂, r.t.

3: 66 percent / 1M LiOH / methanol / Ambient temperature

With lithium hydroxide; sodium hydroxide; potassium tert-butylate; In methanol;

DOI:10.1248/cpb.38.2020

upstream raw materials:

N-benzyloxycarbonyl-N'-(tert-butyloxycarbonyl)-Z-α,β-didehydrotryptophan

(S)-N-benzyloxycarbonyl-L-tryptophan methyl ester

Indole-3-carboxaldehyde

1-tert-butoxycarbonyl-3-formylindole