N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester

Base Information

Chemical Name:N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester
CAS No.:1079398-70-1
Molecular Formula:C₅₂H₆₉N₅O₁₂S
Molecular Weight:988.212
Hs Code.:

N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester

Synonyms:N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester

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Chemical Property of N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester

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Technology Process of N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester

There total 16 articles about N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1079398-49-4
5-(methanesulphonyl-methyl-amino)-isophthalic acid mono-tert-butyl ester

: 1079398-69-8
(1R/S-{3-[2S-amino-5R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)3S-hydroxy-5R-methoxypentyloxy]-phenyl}-2-phenylethyl)-carbamic acid tert-butyl ester

: 1079398-70-1
N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: C₂₆H₂₉NO₃

: 1079398-70-1
N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 7 h / 20 °C

2: potassium carbonate / acetone / 20 °C

3: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane / 70 °C

4: triphenylphosphine / methanol; water / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

With 2-hydroxypyridin; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 873-62-1
m-cyanophenol

: 1079398-70-1
N-{4R-( 1S-benzylcarbamoyl-2-methylpropylcarbamoyl) 1S-[3-( 1 R/S-tert-butoxycarbonylamino-2-phenylethyl)-phenoxymethyl]-2S-hydroxy-4R-methoxybutyl}-5-(methanesulphonyl-methylamino)-isophtalamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetone / 20 °C

2.1: tetrahydrofuran / 2.5 h / 0 - 60 °C

2.2: 2 h / 60 °C

2.3: 0 °C

3.1: ethyl acetate

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 7 h / 20 °C

5.1: potassium carbonate / acetone / 20 °C

6.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane / 70 °C

7.1: triphenylphosphine / methanol; water / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

With 2-hydroxypyridin; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;