N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide
CAS No.:1599473-45-6
Molecular Formula:C₁₉H₂₁NO₃S
Molecular Weight:343.447
Hs Code.:

Synonyms:N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide

There total 4 articles about N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 917-64-6
methyl magnesium iodide

: 1599473-58-1
C₁₈H₁₇NO₄S

: 1599473-45-6
N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 - 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ja5029028

Reference yield:

: 147298-29-1
methyl 2-(2-bromoethynyl)benzoate

: 1599473-45-6
N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 12 h / 70 °C / Inert atmosphere

2: tetrahydrofuran; diethyl ether / 2 h / -78 - 0 °C / Inert atmosphere

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/ja5029028

Reference yield:

: 610-97-9
o-iodo-methyl-benzoic acid

: 1599473-45-6
N-[2-(2-hydroxy-2-propyl)phenylethynyl]-N-methyl-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: silver nitrate; N-Bromosuccinimide / acetone / 2 h / 20 °C / Inert atmosphere

3.1: potassium carbonate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 12 h / 70 °C / Inert atmosphere

4.1: tetrahydrofuran; diethyl ether / 2 h / -78 - 0 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; silver nitrate; diisopropylamine; In tetrahydrofuran; diethyl ether; acetone; toluene;
DOI:10.1021/ja5029028