tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate
CAS No.:1353642-13-3
Molecular Formula:C₁₉H₂₈N₆O₂
Molecular Weight:372.47
Hs Code.:

Synonyms:tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate

There total 3 articles about tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 863671-47-0
tert-butyl (2S)-2-({5-[(4-methylphenyl)sulfonyl]-1H-tetrazol-1-yl}methyl)pyrrolidine-1-carboxylate

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1353642-13-3
tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate

Guidance literature:: (R)-1-phenyl-ethyl-amine; With methylmagnesium chloride; In tetrahydrofuran; at -10 ℃; for 1h; Inert atmosphere;

tert-butyl (2S)-2-({5-[(4-methylphenyl)sulfonyl]-1H-tetrazol-1-yl}methyl)pyrrolidine-1-carboxylate; In tetrahydrofuran; at -40 - 20 ℃;
DOI:10.1021/jo2022235

Reference yield:

: 168049-26-1
tert-butyl (2S)-2-(azidomethyl)-1-pyrrolidinecarboxylate

: 1353642-13-3
tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 48 h / 80 °C

2.1: methylmagnesium chloride / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere

2.2: -40 - 20 °C

With methylmagnesium chloride; In tetrahydrofuran;
DOI:10.1021/jo2022235

Reference yield:

: 132482-09-8
tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate

: 1353642-13-3
tert-butyl (2S)-2-[(5-{[(1R)-1-phenylethyl]amino}-1H-tetrazol-1-yl)methyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 24 h / 80 °C

2.1: 48 h / 80 °C

3.1: methylmagnesium chloride / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere

3.2: -40 - 20 °C

With sodium azide; methylmagnesium chloride; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo2022235