(S)-2-(AzidoMethyl)-1-Boc-pyrrolidine

Base Information

• Chemical Name: (S)-2-(AzidoMethyl)-1-Boc-pyrrolidine
• CAS No.: 168049-26-1
• Molecular Formula: C10H18N4O2
• Molecular Weight: 226.279
• Hs Code.: 2933990090
• Mol file: 168049-26-1.mol

Synonyms:(S)-2-(Azidomethyl)-1-(tert-butoxycarbonyl)pyrrolidine;tert-Butyl (S)-2-(azidomethyl)-1-pyrrolidinecarboxylate;N-Boc-2-azidomethylpyrrolidine;(S)-tert-butyl 2-(azidomethyl)pyrrolidine-1-carboxylate;tert-butyl (2S)-2-(azidomethyl)-1-pyrrolidinecarboxylate;N-Boc-(S)-2-azidomethylpyrrolidine;2-azidomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;(S)-2-(azidomethyl)-1-Boc-pyrrolidine;

Chemical Property of (S)-2-(AzidoMethyl)-1-Boc-pyrrolidine

Chemical Property:

• PSA: 79.29000
• LogP: 2.08686
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-2-(Azidomethyl)-1-Boc-pyrrolidine ≥95% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of (S)-2-(AzidoMethyl)-1-Boc-pyrrolidine

There total 14 articles about (S)-2-(AzidoMethyl)-1-Boc-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate (86661-32-7) → tert-butyl (2S)-2-(azidomethyl)-1-pyrrolidinecarboxylate (168049-26-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 70 ℃; for 6h;

DOI:10.3987/COM-08-S(F)121

Reference yield: 92.0%

tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate (132482-09-8) → tert-butyl (2S)-2-(azidomethyl)-1-pyrrolidinecarboxylate (168049-26-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1016/j.bmcl.2009.06.006

Reference yield: 75.0%

N-(tert-butoxycarbonyl)-L-prolinol (69610-40-8) → tert-butyl (2S)-2-(azidomethyl)-1-pyrrolidinecarboxylate (168049-26-1)

Guidance literature:

With hydrogen azide; di-isopropyl azodicarboxylate; triphenylphosphine; In benzene; at 0 - 20 ℃; for 0.833333h;

DOI:10.1055/s-0033-1339291

upstream raw materials:

tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate

(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate

tert-butyl (2S)-2-[(phenylselenonyl)methyl]pyrrolidine-1-carboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyrrolidin-2-ylmethyl)thiourea hydrochloride

C₂₀H₁₈F₆N₄OS

1-[(2S)-1-methylpyrrolidin-2-yl]methanamine

Refernces

• 1、 Kaasik, Mikk,Kaabel, Sandra,Kriis, Kadri,J?rving, Ivar,Kanger, T?nis. "Synthesis of Chiral Triazole-Based Halogen Bond Donors". supporting information. p. 2128 - 2135. Retrieved 2019/05/10.
• 2、 -. "COMPOUNDS FOR REACTIVATION OF ACETYLCHOLINESTERASE AND RELATED COMPOSITIONS METHODS AND SYSTEMS". Paragraph 0371. . Retrieved 2017/12/27.