1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate

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Chemical Name:1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate
CAS No.:868699-76-7
Molecular Formula:C₂₈H₄₂FN₃O₅
Molecular Weight:519.657
Hs Code.:

Synonyms:1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate

There total 4 articles about 1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40500-05-8
2-(tetrahydro-2H-pyran-4-yl)acetyl chloride

: 928300-13-4
1,1-dimethylethyl 4-({[3-fluoro-4-(4-morpholinyl)phenyl]amino}methyl)-1-piperidinecarboxylate

: 868699-76-7
1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; for 72h;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 868699-76-7
1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1.25 h / 0 - 20 °C / Cooling with ice-salt bath

2: hydrogen / palladium 10% on activated carbon / ethanol / 18 h

3: sodium tris(acetoxy)borohydride / dichloromethane / 18 h

4: triethylamine / dichloromethane / 72 h

With hydrogen; sodium tris(acetoxy)borohydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 2689-39-6
3-fluoro-4-(4-morpholinyl)nitrobenzene

: 868699-76-7
1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h

3: triethylamine / dichloromethane / 72 h

With hydrogen; sodium tris(acetoxy)borohydride; triethylamine; palladium 10% on activated carbon; In ethanol; dichloromethane;