40500-05-8

Basic information

• Product Name: TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE
• Synonyms: TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE;Tetrahydropyran-4-acetyl chloride ,95%;tetrahydropyran-4-ylacetyl chloride;Tetrahydropyran-4-ylacetyl chloride ,95%;4-(2-Chloro-2-oxoethyl)tetrahydro-2H-pyran, 4-(2-Chloro-2-oxoethyl)oxane;2-(tetrahydro-2H-pyran-4-yl)acetyl chloride;4-(2-Chloro-2-oxoethyl)tetrahydro-2H-pyran
• CAS NO: 40500-05-8
• Molecular Formula: C₇H₁₁ClO₂
• Molecular Weight: 162.61404
• Product Categories: Carbonyl Chlorides;Pyrans, Piperidines &Piperazines;Carbonyl Chlorides;Pyrans, Piperidines & Piperazines
• Mol File: 40500-05-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 223.8 °C at 760 mmHg
• Flash Point: 83 °C
• Appearance: /
• Density: 1.132 g/cm³
• Vapor Pressure: 0.0944mmHg at 25°C
• Refractive Index: 1.453
• CAS DataBase Reference: TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE(40500-05-8)
• EPA Substance Registry System: TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE(40500-05-8)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 40500-05-8(Hazardous Substances Data)

Usage

General Description

Tetrahydro-2H-pyran-4-ylacetyl chloride is a chemical compound with the molecular formula C8H13ClO2. It is a chlorinated derivative of tetrahydropyran-4-ylacetic acid and is commonly used in organic synthesis as a reagent for the acetylation of alcohols and amines. It is a clear, colorless liquid with a strong acrid odor and is highly reactive, making it useful in the production of various pharmaceuticals and agrochemicals. Its main application is in the formation of esters and amides, and it is also used as an intermediate in the synthesis of other organic compounds. The compound should be handled with care as it is corrosive and can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H11ClO2/c8-7(9)5-6-1-3-10-4-2-6/h6H,1-5H2

Upstream product

• 85064-61-5 2-(tetrahydro-2H-pyran-4-yl)acetic acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1403670-52-9 C₃₀H₃₄ClN₃O₆ 
• 1247873-84-2 N-{2-[(3-chlorophenyl)amino]-4-(trifluoromethyl)pyrimidin-5-yl}-2-(tetrahydro-2H-pyran-4-yl)acetamide 
• 929612-73-7 1-phenyl-4-(tetrahydro-2H-pyran-4-ylacetoxy)-1,8-naphthyridin-2(1H)-one 
• 868699-76-7 1,1-dimethylethyl 4-{[(3-fluoro-4-(4-morpholinyl)phenyl)(tetrahydro-2H-pyran-4-ylacetyl)amino]methyl}-1-piperidinecarboxylate 
• 815618-35-0 (R)-4-benzyl-3-(2-(tetrahydro-2H-pyran-4-yl)acetyl)oxazolidin-2-one 
• 959937-91-8 N-{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethylethyl}-2-(tetrahydropyran-4-yl)acetamide 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES

The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Design and Synthesis of Natural Product Inspired Libraries Based on the Three-Dimensional (3D) Cedrane Scaffold: Toward the Exploration of 3D Biological Space

A chemoinformatic method was developed to extract nonflat scaffolds embedded in natural products within the Dictionary of Natural Products (DNP). The cedrane scaffold was then chosen as an example of a nonflat scaffold that directs substituents in three-dimensional (3D) space. A cedrane scaffold that has three orthogonal handles to allow generation of 1D, 2D, and 3D libraries was synthesized on a large scale. These libraries would cover more than 50% of the natural diversity of natural products with an embedded cedrane scaffold. Synthesis of three focused natural product-like libraries based on the 3D cedrane scaffold was achieved. A phenotypic assay was used to test the biological profile of synthesized compounds against normal and Parkinson's patient-derived cells. The cytological profiles of the synthesized analogues based on the cedrane scaffold revealed that this 3D scaffold, prevalidated by nature, can interact with biological systems as it displayed various effects against normal and Parkinson's patient-derived cell lines.

QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.