(1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

Base Information

Chemical Name:(1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol
CAS No.:1308324-63-1
Molecular Formula:C₂₅H₃₈O₉
Molecular Weight:482.571
Hs Code.:

Synonyms:(1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

Suppliers and Price of (1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

There total 10 articles about (1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1308324-62-0
(4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4R,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-one

: (1R,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

: 1308324-63-1
(1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

Guidance literature:: (4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4R,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-one; With (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In dichloromethane; at -78 - 0 ℃; for 3h; Molecular sieve; Inert atmosphere;

With methanol; In dichloromethane; at 0 - 20 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.02.010

Reference yield:

: 1308324-56-2
(1S)-1-{(4S,5S)-5-[(benzyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}ethane-1,2-diol

: 1308324-63-1
(1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; di(n-butyl)tin oxide; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux; Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

4.1: ammonia; lithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 20 °C / Cooling with ice; Inert atmosphere

6.1: ethylmagnesium bromide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.2: 2 h / Reflux

7.1: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere

8.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / dichloromethane / 3 h / -78 - 0 °C / Molecular sieve; Inert atmosphere

8.2: 0 - 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; ethylmagnesium bromide; ammonia; lithium; di(n-butyl)tin oxide; Dess-Martin periodane; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2011.02.010

Reference yield:

: 1308324-57-3
C₂₂H₂₈O₇S

: 1308324-63-1
(1S,4R)-6-[(4-methoxybenzyl)oxy]-4-(methoxymethoxy)-1-{(4S,5S)-5-[(1S)-1-(methoxymethoxy)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hexyn-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux; Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

3.1: ammonia; lithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 20 °C / Cooling with ice; Inert atmosphere

5.1: ethylmagnesium bromide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.2: 2 h / Reflux

6.1: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere

7.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / dichloromethane / 3 h / -78 - 0 °C / Molecular sieve; Inert atmosphere

7.2: 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ethylmagnesium bromide; ammonia; lithium; Dess-Martin periodane; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2011.02.010