(2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester

Base Information

Chemical Name:(2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester
CAS No.:167275-77-6
Molecular Formula:C₂₆H₃₉Cl₃N₂O₈Si
Molecular Weight:642.049
Hs Code.:

(2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester

Synonyms:(2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester

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Chemical Property of (2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester

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Technology Process of (2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester

There total 10 articles about (2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: Amino-acetic acid 2,2,2-trichloro-ethyl ester; hydrochloride

: 207510-42-7
(2S,3S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-succinic acid 4-benzyl ester

: 167275-77-6
(2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; diethyl cyanophosphonate; In N,N-dimethyl-formamide; at 0 ℃; for 20h;
DOI:10.1055/s-1998-5937

Reference yield:

: (2S,3S)-2-tert-Butoxycarbonylamino-3-hydroxy-succinic acid 4-benzyl ester

: 167275-77-6
(2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 40.5 h

2: Et₃N, diethyl phosphorocyanidate

With 1H-imidazole; diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1055/s-1998-5937

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 167275-77-6
(2S,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-N-(2,2,2-trichloro-ethoxycarbonylmethyl)-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TEA / dioxane; H₂O

2: imidazole / dimethylformamide

3: diethyl phosphorocyanidate, Et₃N / dimethylformamide

With 1H-imidazole; diethyl cyanophosphonate; TEA; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00134a035