2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen

Base Information

• Chemical Name: 2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen
• CAS No.: 73394-17-9
• Molecular Formula: C₂₂H₁₇NO₄S₂
• Molecular Weight: 423.513

Synonyms:2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen

Chemical Property of 2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen

Chemical Property:

Purity/Quality:

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Technology Process of 2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen

There total 3 articles about 2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-{2-Oxo-2-[2-(toluene-4-sulfonylamino)-phenyl]-ethylsulfanyl}-benzoic acid methyl ester (343796-20-3) → 2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen (73394-17-9)

Guidance literature:

With sodium methylate; In methanol; benzene; 1.) reflux, 1.5 h, 2.) room temp., 1 h;

DOI:10.1002/ardp.19803130107

Reference yield:

N-(2-acetylphenyl)-4-methylbenzenesulfonamide (1859-70-7) → 2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen (73394-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / Br₂ / CHCl₃ / 1 h / Irradiation

2: 77 percent / NaOCH₃ / methanol / Ambient temperature

3: 70 percent / NaOCH₃ / benzene; methanol / 1.) reflux, 1.5 h, 2.) room temp., 1 h

With bromine; sodium methylate; In methanol; chloroform; benzene;

DOI:10.1002/ardp.19803130107

Reference yield:

2-Tosylamino-α-bromoacetophenone (4688-65-7) → 2-(2-Tosylaminobenzoyl)-3-hydroxy-benzothiophen (73394-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / NaOCH₃ / methanol / Ambient temperature

2: 70 percent / NaOCH₃ / benzene; methanol / 1.) reflux, 1.5 h, 2.) room temp., 1 h

With sodium methylate; In methanol; benzene;

DOI:10.1002/ardp.19803130107

upstream raw materials:

2-{2-Oxo-2-[2-(toluene-4-sulfonylamino)-phenyl]-ethylsulfanyl}-benzoic acid methyl ester

N-(2-acetylphenyl)-4-methylbenzenesulfonamide

2-Tosylamino-α-bromoacetophenone

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