1859-70-7

Basic information

• Product Name: Benzenesulfonamide, N-(2-acetylphenyl)-4-methyl-
• CAS NO: 1859-70-7
• Molecular Formula: C15H15NO3S
• Molecular Weight: 289.355
• Mol File: 1859-70-7.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(2-acetylphenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(2-acetylphenyl)-4-methyl-(1859-70-7)
• EPA Substance Registry System: Benzenesulfonamide, N-(2-acetylphenyl)-4-methyl-(1859-70-7)

Safety Data

• Hazardous Substances Data: 1859-70-7(Hazardous Substances Data)

Upstream product

• 551-93-9 2-aminoacetophenone 
• 98-59-9 p-toluenesulfonyl chloride 
• 4127-53-1 3-methylbenzo[c]isoxazole 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 577-59-3 2-acetylnitrobenzene 
• 2142-69-0 2-bromophenyl methyl ketone 
• 70-55-3 toluene-4-sulfonamide 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 941-55-9 4-toluenesulfonyl azide 
• 98-86-2 acetophenone 
• 75-16-1 methylmagnesium bromide 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 118-92-3 anthranilic acid 
• 31659-28-6 N-(2-Cyanophenyl)-4-methylbenzenesulfonamide 

Downstream Products

• 869668-71-3 2-(2-bromophenyl)-1-[2-N-(4-methylbenzenesulfonamido)phenyl]ethanone 
• 925668-90-2 2-(2-bromo-4,5-dimethylphenyl)-1-[2-N-(4-methylbenzenesulfonamido)phenyl]ethanone 
• 36797-43-0 3-methyl-N-(p-toluenesulfonyl)indole 
• 83-34-1 3-Methylindole 
• 1261245-29-7 N-(2-(2-hydroxypent-4-en-2-yl)phenyl)-4-methylbenzenesulfonamide 
• 1359967-02-4 C₂₇H₂₇NO₄S 
• 1448808-75-0 3-(diiodomethyl)-3-methyl-1-tosylindolin-2-one 
• 43154-30-9 N-[2-(4-methylphenylsulfonamido)phenyl]acetamide 
• 767288-71-1 3-methyl-1-(4-methylphenylsulfonyl)indazole 
• 56969-73-4 (4-methylquinolin-3-yl)(phenyl)methanone 
• 106745-67-9 N-(2-(1-methylethenyl)phenyl)-4-methylbenzenesulfonamide 
• 36004-73-6 3-methyl-1-(toluene-4-sulfonyl)-indole-2-carboxylic acid methyl ester 
• 10590-73-5 3-methylindole-2-carboxylic acid 
• 161837-25-8 (E)-N-{2-[3-(dimethylamino)acryloyl]phenyl}-4-methylbenzenesulfonamide 

Relevant articles and documents

An advantageous route to oxcarbazepine (Trileptal) based on palladium-catalyzed arylations free of transmetallating agents

(Chemical Equation Presented) A new route to oxcarbazepine (Trileptal), the most widely prescribed antiepileptic drug, starting from commercially available 2′-aminoacetophenone and 1,2-dibromobenzene, is reported. The sequentially accomplished key steps are palladium-catalyzed intermolecular α-arylation of ketone enolates and intramolecular N-arylation reactions. After several experiments to establish the best conditions for both arylation processes, the target oxcarbazepine is obtained in a satisfactory overall yield, minimizing the number of steps and employing scalable catalytic procedures developed in partially aqueous media.

Iron-Catalyzed Electrophilic Amination of Sodium Sulfinates with Anthranils

A practical method for the synthesis of N-(2-carbonylaryl) benzenesulfonamides via an iron-catalyzed electrophilic amination of sodium sulfinates with anthranils is described. This redox-neutral transformation has high atom efficiency and is achieved under simple and mild reaction conditions. A wide range of anthranils and sodium sulfinates were compatible in this transformation. Moreover, the synthetic potential of this methodology was further demonstrated by the synthesis of various useful N-heterocycles and derivatives.

Visible-light-promoted N-centered radical generation for remote heteroaryl migration

Herein, an efficient visible-light-mediated N-H heteroarylationviaremote heteroarylipso-migration has been accomplished. Moderate to good yields were obtained with good functional group tolerance. Moreover, a simple and readily available organic photoredox catalyst was employed, avoiding the use of complex and costly noble metal compounds.

Domino Aryne Annulation via a Nucleophilic-Ene Process

1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.