3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester

Base Information

• Chemical Name: 3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester
• CAS No.: 81593-47-7
• Molecular Formula: C₂₅H₃₃NO₅
• Molecular Weight: 427.541
• Mol file: 81593-47-7.mol

Synonyms:3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester

Chemical Property of 3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester

There total 4 articles about 3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.8%

4-[2-(4-Methoxy-benzyl)-pyrrolidin-1-yl]-butan-1-ol (81593-72-8) + 3,4-dimethoxybenzoic acid chloride (3535-37-3) → 3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester (81593-47-7)

Guidance literature:

With triethylamine; In benzene; for 3h; Heating;

DOI:10.1248/cpb.30.180

Reference yield:

2-(4-methoxybenzyl)pyrrolidine (66162-38-7) → 3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester (81593-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / triethylamine / benzene / 1.) 1 h, room temp., 2.) 2 h, reflux

2: 65.5 percent / LiAlH₄ / tetrahydrofuran / 1.) 0.5 h, room temp., 2.) 4 h, reflux

3: 77.8 percent / triethylamine / benzene / 3 h / Heating

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1248/cpb.30.180

Reference yield:

5-(4-methoxy-benzyl)-pyrrolidin-2-one (26052-80-2) → 3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester (81593-47-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / LiAlH₄ / tetrahydrofuran / 1.) 0.5, room temp., 2.) 4 h, reflux

2: 72 percent / triethylamine / benzene / 1.) 1 h, room temp., 2.) 2 h, reflux

3: 65.5 percent / LiAlH₄ / tetrahydrofuran / 1.) 0.5 h, room temp., 2.) 4 h, reflux

4: 77.8 percent / triethylamine / benzene / 3 h / Heating

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1248/cpb.30.180

upstream raw materials:

4-[2-(4-Methoxy-benzyl)-pyrrolidin-1-yl]-butan-1-ol

3,4-dimethoxybenzoic acid chloride

2-(4-methoxybenzyl)pyrrolidine

5-(4-methoxy-benzyl)-pyrrolidin-2-one